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KMID : 0362919860040020089
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1986 Volume.4 No. 2 p.89 ~ p.97
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Dose-Response Curves of Mouse Jejunal Crypt Cells by Multifrationated Irrdiation
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Hong Seong-Eon
Ahn Chi-Yul
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Abstract
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Using as assay for jejunal crypt stem cell survival, dose-response curves for the reproductive capacity of crypt stem cells mouse jejunum exposed to multifractionated gamma-ray irradiation(single, 2, 3, 4, 5, 6, 7, 8, 10,12, and 16 fractions) were analyzed and single-dose survival curve of these cells was constructed.
The following conclusion were drawn:
1) Survival curves for higher numbers of dose fractions were displaced to higher dose, and characterized by increasingly shallower slopes.
2) The single-dose survival curve had broad shoulder, Dq=460 cGy, remaining near-exponential over initial dose range 0 to 300 cGy, with initial slope 1Do=474 cGy
3) At fractionated dose in the range of 180 to 450 cGy, the average recovered dose per fraction interval was approximately 50% of the dose per fraction.
4) The value of a/b ratio by using of linear regression analysis for the reciprocal dose plots was 8.3㏉ which lied in the range of 6-14㏉ for early-reacting tissues.
5) The linear-quadratic model for dose-response formula offers valid approximations for all doses to be used in radiotherapy, only two parameters to be determined, and considerable convenience in practical applications.
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KEYWORD
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Radiation, Fractionation, jejunal crypt
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